The strike hit a five-story building in the area of Beit Lahiya, where families of displaced Palestinians were taking shelter. At least 25 of those killed were children, according to health officials.
The Israeli military said it is aware of civilian deaths and is "looking into" the incident.
The attack comes as Israeli forces have hindered medical and rescue services in the area, and as Israeli parliament voted to ban the main United Nations agency that provides aid to Palestinians, UNRWA.
TVNL Comment: AT LEAST 25 OF THE DEAD WERE CHILDREN!!! There are no medical or rescue services to help those in need. Does anyone care?