Reovirus, which lives in human respiratory and gastrointestinal tracts without causing any symptoms, can help magnify the effects of radiotherapy in treating even the most advanced cancers, laboratory tests have shown.
Tumours shrank or stopped growing in every patient who underwent radiotherapy coupled with a new drug, Reolysin, which contains particles of reovirus.
A total of 23 patients with a range of solid tumours including lung, bowel, ovarian and skin cancers took part in the clinical trial. All had stopped responding to traditional therapies but were able to get some pain relief from radiation treatment.
The primary aim was to test whether the treatment was safe, but researchers also measured tumour responses for 14 patients. Tumours either shrank or stopped growing in every case, the scientists reported in the journal Clinical Cancer Research.
The side effects of the treatment were mild and typical of patients receiving radiotherapy alone.
